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High Blood Pressure Ace Inhibitor Drugs at Aging and Disease



High Blood Pressure medicine angiotensin converting enzyme (ACE) inhibitors and the angiotensin receptor blocker (ARB) high blood pressure medicine both affect the renin-angiotensin hormonal system, which, as mentioned previously, helps regulate the high blood pressure. The ACE inhibitors work by blocking (inhibiting) an enzyme that converts the inactive form of angiotensin in the blood to its active form. The active form of angiotensin constricts or narrows the arteries, but the inactive form cannot. With an ACE inhibitor as a high blood pressure medicine, 50 to 60 percent of Caucasians usually achieve good blood pressure control.

In patients who have high blood pressure in addition to certain second diseases, a combination of an ACE inhibitor and an ARB drug may be effective in controlling the high blood pressure and also benefiting the second disease. For example, while treating hypertension, this combination of drugs can reduce the loss of protein in the urine (proteinuria) in certain kidney diseases and perhaps help strengthen the heart muscle in certain diseases of the heart muscle (cardiomyopathies). Note that both the ACE inhibitor high blood pressure medicine and the ARB drugs are not to be used in pregnant women.

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